📄 Research Article
PAMAJ Vol. 1, No. 4 (2022)
Pharmacological Potential of DHFCOP-A,Oil Palm empty bunch derivative on Triple Negative Breast Cancer Patient-Derived Xenograft Mice Models
Dr Uzoamaka Adaobi Okoli 1 & Dr Michael Tochukwu Okafor 2 & Prof Chioli Pascal Chijioke 2 & Prof Iroka Joseph Udeinya 3
1 Department of Pharmacology and TherapeuticsUniversity of Nigeria
2 University of Nigeria, Enugu Campus
3 Enugu State University of Science and Technology, Enugu State, Nigeria
2 University of Nigeria, Enugu Campus
3 Enugu State University of Science and Technology, Enugu State, Nigeria
Open Access
Peer Reviewed
Research Article
Abstract
Introduction: Triple-Negative Breast Cancer (TNBC) is clinically aggressive. There is growing evidence that the tumour microenvironment's low pH (acidity) tends to boost cancer aggressiveness. The acidity of the tumour microenvironment tends to correlate with high TNBC chemo-resistance. Strategic manipulation to raise the tumour microenvironment's pH may help discover new anti-cancer therapies. An anhydrous chemical, DFHCOP-A has high pH of 10.5 and is remarkably non-corrosive. However, no known study has established the effect of DFHCOP-A in altering tumour microenvironment pH.Material and Methods: Ethical clearance was given. Patient-Derived Xenograft (PDX) model was derived from a consenting Nigerian woman with TNBC who had undergone mastectomy. 100mg/kg, 300mg/kg and vehicle of DFHCOP-A were administered to mice models after 1-week xenograft and 6-weeks xenograft in a time/dose-dependent manner.Results and Discussions: 100mg/kg DFHCOP-A treatment inhibited cancer growth while 300mg/kg DFHCOP-A had no significant effect on cancer growth compared to vehicle control after 1-week xenograft. Paradoxically, there was a significant elevation of serum pH and ionic calcium depletion in the 100mg/kg treated group compared to the vehicle control and 300mg/kg-treated groups.Conclusion: This study provides preliminary evidence that DFHCOP-A at a low dose may increase the pH of the tumour microenvironment to potentiate cancer drugs.Keywords: Hormesis; Triple Negative Breast Cancer; pH; Tumour microenvironment; patient-derived xenograft; Nigerian woman; DFHCOP-A, ionic calcium, Lactate, Anion Gap, Serum Electrolytes, serum pH
Keywords:
Triple Negative Breast Cancer, pH, Tumour microenvironment, patient-derived xenograft, DFHCOP-A
📑 How to Cite This Article
APA 7th Edition:
Dr Uzoamaka Adaobi Okoli, Dr Michael Tochukwu Okafor, Prof Chioli Pascal Chijioke, Prof Iroka Joseph Udeinya (2022). Pharmacological Potential of DHFCOP-A,Oil Palm empty bunch derivative on Triple Negative Breast Cancer Patient-Derived Xenograft Mice Models. Pharmacology and Alternate Medicine Academic Journal, 1(4), 1-13. https://doi.org/
Dr Uzoamaka Adaobi Okoli, Dr Michael Tochukwu Okafor, Prof Chioli Pascal Chijioke, Prof Iroka Joseph Udeinya (2022). Pharmacological Potential of DHFCOP-A,Oil Palm empty bunch derivative on Triple Negative Breast Cancer Patient-Derived Xenograft Mice Models. Pharmacology and Alternate Medicine Academic Journal, 1(4), 1-13. https://doi.org/
Vancouver Style:
Dr Uzoamaka Adaobi Okoli, Dr Michael Tochukwu Okafor, Prof Chioli Pascal Chijioke, Prof Iroka Joseph Udeinya. Pharmacological Potential of DHFCOP-A,Oil Palm empty bunch derivative on Triple Negative Breast Cancer Patient-Derived Xenograft Mice Models. Pharmacol. Alt. Med. Acad. J.. 2022;1(4):1-13. DOI:
Dr Uzoamaka Adaobi Okoli, Dr Michael Tochukwu Okafor, Prof Chioli Pascal Chijioke, Prof Iroka Joseph Udeinya. Pharmacological Potential of DHFCOP-A,Oil Palm empty bunch derivative on Triple Negative Breast Cancer Patient-Derived Xenograft Mice Models. Pharmacol. Alt. Med. Acad. J.. 2022;1(4):1-13. DOI:
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