Hypertension is increasingly recognized as a major global health challenge, with rising prevalence contributing to significant morbidity and mortality from cardiovascular and kidney diseases. Despite existing preventive efforts, the age of onset in Nigeria is decreasing, highlighting the need for more effective strategies. Lifestyle factors such as poor diet, physical inactivity, and substance use are key contributors to hypertension, while educational interventions have been shown to improve awareness and adoption of preventive behaviors. This study investigates the influence of nurse-led health education on knowledge and lifestyle practices related to hypertension prevention among adult residents of Ogbomoso, Oyo State, Nigeria. Findings are expected to inform community-based strategies for promoting lifestyle modifications, enhancing preventive knowledge, and reducing the burden of hypertension in similar settings.