This study was carried out to examine the influence of strategic agility on organizational performance in selected manufacturing firms in South-south Nigeria. Strategic agility was proxied into strategic leadership and flexibility. Survey research design was adopted for the study. The total population was 319 staff of selected quoted manufacturing firms in South-South Nigeria. 177 was arrived at as sample size, using Taro Yamene’s formula for sample size determination. Both primary and secondary sources of data were employed for the study. Proportionate sampling technique was adopted to ensure efficient representation of each firm while the research instrument was a structure questionnaire. Descriptive and Inferential statistics were used in analyzing the study. Findings revealed that strategic leadership had a high correlation value of R = 0. 861 with an Unstandardized Coefficient Beta β=0.666. While flexibility showed an Unstandardized Coefficient Beta of β=0.766. From the findings, it was concluded that strategic agility has a positive significant influence on organizational performance in selected manufacturing firms in South-south Nigeria. As such, it is recommended that management of selected manufacturing firms in south-south Nigeria should embrace strategic leadership as it will empower their organizations to navigate complex and ever-changing business landscapes successfully. Equally, management of selected manufacturing firms in south-south should inculcate flexibility as one of their core operational policy if they are to thrive in a dynamic environment.