The number of persons working with display screen equipment is constantly growing with many training to master the use of display screening equipment. Unfortunately, mane of the users are unaware of the health problems associated nor armed with measures to protect themselves against the numerous health problems. And the situation is worst in developing countries where Occupational health safety guidelines are poorly implemented, enforced and practices by industries. Hence, this paper explored the various health problems associated with the use display screen equipment with proper illustrations as well as proffered practices solution to preventing, controlling the health problems and the protection of the workers both small, medium and large-scale industries. It was also suggested among others that Proper health and safety training must be made available for all work stations which will basically Include how to adjust furniture and the most correct and comfortable way to sit while using the work station and employers should make available to their employees, ergonomic DSE work stations to help reduce the negative effect of work on the employees.