Atopic Dermatitis (AD) significantly affects the quality of life (QOL) of children due to persistent itching and visible skin lesions, while caregivers often experience considerable psychological stress. This review examines six randomized controlled trials evaluating nonchemical interventions aimed at improving both QOL and disease severity in pediatric AD patients. Most interventions involved educational programs, with one study exploring the impact of viewing humorous films on sleep quality. Findings indicate that educational interventions consistently reduced disease severity compared to no intervention. Nurse-led clinics were more effective than dermatologist-led clinics, and video-based parental education showed greater benefits than direct teaching. Additionally, watching humorous films before bedtime decreased night-time awakenings. However, methodological limitations in four of the studies weaken the conclusiveness of the results. The review highlights the potential of educational and behavioral strategies in managing AD and enhancing pediatric QOL, emphasizing the need for more rigorously designed trials to validate and replicate these interventions effectively.