Mosquitoes are vectors that are responsible for malaria, thus many families have indulged in using mosquito coil in order to control its spread. This study aimed on investigation of selected inflammatory biomarkers and lungs histomorphology of Rattus norvegicus (Norway rats) exposed to Kill-Fast mosquito coil smoke. One milliliter of blood specimen was withdrawn from five groups of four male rats per group with mean weight 0.330 ± 0.05 kg exposed to approximately15 mg concentration of Kill-Fast mosquito coil smoke for 30, 60, 90 and 120 days (experimental groups) respectively with the exception of the control group. This was followed by the measurement of inflammatory biomarkers: C-reactive protein (latex turbidimetry) method and interleukin-6 (ELISA) method as well as lungs histomorphology assessment of the rats after anaesthesizing with chloroform technique and excised. The data were analyzed using SPSS version 23.0 (SPSS Inc., Chicago, IL, USA; Version 23.0) and analysis of variance (ANOVA) was used for the statistical analysis. The results revealed significant mean values elevation of C-reactive protein (p<0.01) and interleukin-6 (p<0.01) in the rats exposed to the smoke of this coil for 30, 60, 90 and 120 days respectively as compared to control. These significant mean values elevations corroborated with the lungs histomorphological assessment of the Rattus norvegicus (Norway rats). In conclusion, inflammatory disorder as well as histomorphological alterations of the lungs, were established in the experimental Rattus norvegicus (Norway rats). It is therefore recommended that the biochemical aspect of this study should be carried out in users of Kill-Fast mosquito coil so as to ascertain if the same findings will be obtained