This descriptive study explored use of personal Protective Equipment in the prevention of Industrial Mishapsin the United Cement Company of Nigeria (UNICEM) in Calabar, Cross River State, Nigeria. Four (4) hypotheses were formulated to direct the investigation. Two Hundred and Thirty (230) respondents drawn from the population of workers in various departments, Quarry, Health, Production, Electrical, Mechanical, Transportation, Security/ Surveillance and Occupational Health & Safety, of the company were used for the study. Data were collected using well designed and validated structured questionnaire. Data collected were subjected to statistical analysis using Chi-square (X2) test statistics. Results obtained indicated a positive significant relationship between the use of PPE and prevention of industrial problems in terms of inhalation of cement dust, eye and ear disorders and workplace injuries. It was concluded that proper use of personal Protective Equipment leads to prevention of Industrial Mishaps. From this finding, it was recommended among others the management of cement industries should ensure that personal protective equipment is not only provided for workers but workers are monitored and supervised to ensure strict compliance on the usage by workers