The study investigated the enablers of consumer patronage of cosmetic brands among ladies in Anambra State of Nigeria using Awka, Onitsha and Nnewi as reference areas. The motivation for this research emanated as a result of proliferation of different brands of cosmetic by cosmetics manufacturers without commensurate knowledge on factors that propel consumers to patronize cosmetic brands in Nigeria especially in Anambra State. Accordingly, the study specifically examined the motivating factors and also ascertained the extent brand perceived quality, price, scent, brand name and design influence consumer patronage of selected cosmetic brands in Anambra State of Nigeria. The study employed a survey research design method. The population of the study consist of consumers of cosmetic products under investigation. Bournely’s formula was used to derive a sample size of 380. Respondents were contacted using a convenience sampling strategy. The source of data used was primary while questionnaire was the instrument used for data collection. The validation of the research instrument was done which enhanced its soundness for the main survey. Also, the average variance extracted (AVE) values ranging from 0.501-0.644 which confirmed the convergent validity among the constructs. The reliability of the measuring instrument was checked and established. The Cronbach alpha average coefficient of 0.757 as well as average composite reliability value of 0.756 established the internal consistency of the study constructs. The five formulated hypotheses were tested using a structural equation modelling technique at 5% level of significance. The findings revealed that perceived quality had a significant and positive influence on consumer patronage of cosmetic brands in Anambra State of Nigeria. It was discovered that price had a significant and positive influence on consumer patronage of cosmetic brands. The findings showed that scent had a significant and positive influence on consumer patronage of cosmetic brands. The findings revealed that brand name had a significant and positive influence on consumer patronage of cosmetic brands. Also, the study discovered that brand design had a significant and positive influence on consumer patronage of cosmetic brands. The study recommended among others that cosmetics manufacturers, brand managers and marketers,should,continue to improve on the quality, price, scent, name and design of their various brands of cosmetics for enhanced and sustained consumer patronage in Nigeria.