This research focused on leveraging technology innovation and creativity in entrepreneurship opportunities in Nigeria has gained a competitive edge. The study adopted correlation research design and time horizon of cross sectional design with data generated from dealers in the six geopolitical zones in Nigeria on micro, small and medium enterprise (MSME) goods and services that are the most enterprising entrepreneurs. The study used systematic sampling and non-proportionate stratified random sampling techniques. 540 copies of questionnaire were distributed to the respondents and 497 copies were completed fit for further analysis. The content validity was used for validating the instrument, while the internal consistency reliability was achieved using Cronbach Alpha technique. The reliability coefficient analysis was creativity(α =0.821), innovation (α=0.829) and entrepreneurship opportunities (α=0.799).The synchronization of the principal component was confirmed using Kaiser-Meyer-Olkin (KMO) of (0.904)/(0.861)  and Bartlett's Test matching approx. chi-square (5763.988)/(2158.608)  at 0.000null hypotheses respectively were rejected. Furthermore, Pearson Product Correlation Co-efficient was introduced to test the two hypotheses via SPSS 25 version. From the findings, emergence of leveraging creative innovation influence entrepreneurship opportunities positively. This is the systematic metrics of sustainability, survival and success in the enterprise with high growth. The technology innovation emergence of AI and machine learning transformed industry 3.0, industry 4.0, to industry 5.0. Hence, this navigate entrepreneurs with high spirit of creativity and innovation which could boost entrepreneurship opportunities to business excellence. In conclusion, creativity and innovation revealed significant influence the entrepreneurship opportunities of micro, small and medium enterprise (MSME) goods. Based on the findings and conclusion, this study contributes to the knowledge that  technology innovative culture formed a formidable force applicable to the micro and macro enterprise that influences entrepreneurship opportunities, also emergence of leveraging creative innovation  and entrepreneurship opportunities synchronization is transformation tool for every enterprise to pursuit her vision and mission. It could be recommended that technology innovation should has short-term metrics drawn from the long-term of creativity to avoid deviation from specific goals and corporate objectives.