This study examined the moderating role of organizational structure relationship between Strategic innovation managementand Organizational Survival of the hostels in Port Harcourt. The study used a correlational cross sectional design involving managers,supervisors and unit heads. Primary data was obtained using self- administered, structured questionnaire. The population of the studywas 350 from 20 purposively hotels selected hotels in Port Harcourt. A sample size of 186 was adopted using the Krejcie and Morgantable and the simple random technique was used. The internal reliability of the research instrument was tested using Cronbach AlphaCoefficient and only items that have an alpha reading of 0.70 and above were considered. After data cleaning, only data for 166respondents were suitable for data analysis. Spearman’s rank correlation was used for hypothesis testing while the zero-order partialcorrelation was used to test the moderating role of organizational structure. The study findings revealed that there is a positive andsignificant relationship between strategic innovation management and organizational survival. Furthermore, organizational structuresignificantly moderated the relationship between strategic innovation management and organizational survival. The study recommendsthat hotels should give due attention to the impact of organizational structure since it significantly moderates the relationship betweenStrategic innovation management and Organizational Survival. This should be done by developing less formalized and centralized butmore professionalized and managerially intensive organizational structure that allow them to be responsive to external contingencies.