This study examined the feed intake and weight gain of twenty (20) weaner rabbit of mixed breeds and sexes fed diets with different cassava leaf meal (18.9 % crude protein and 8.67 % crude fibre) inclusions to replace palm kernel cake (PKC) as a protein source at 0% (control, T1), 25% (T2), 50% (T3), 75% (T4) and 100% (T5). Four (4) animals were randomly allocated into each of the five (5) dietary treatments in a Completely Randomized Design (CRD). Feed and water were provided ad libitum for 70 days. The dry matter intake (d/day) obtained during this study were 56.57, 54.88, 52.21, 56.95 and 51.68 for treatments 1, 2, 3, 4 and 5 respectively with no significant difference (P > 0.05) between them. Consequently, the average daily weight gains (g/day) were not affected (P > 0.05) by the dietary treatments with values of 5.45, 4.40, 5.39, 3.57 and 4.55 for treatments 1, 2, 3, 4 and 5 respectively. The intakes of crude protein and organic matter followed a similar pattern, showing no significant difference (P > 0.05) among dietary treatments. Significant variations were observed in the crude fibre (g/day) intakes with values 7.04, 6.61 and 6.08 for treatments 2, 3 and 4 respectively compared to those of treatment 1 (9.43) and treatment 5 (4.48). In addition, the feed conversion efficiency (FCE) differed significantly with the highest from treatment 1 (0.09) and lowest treatment 4 (0.06).  The study revealed that the CLM is rich in nutrients especially crude protein and it can be used as a partial or total replacement for PKC, however there may be cases of diarrhoea which can be avoided if the crude fibre requirement is met.