This paper investigated the effect of accounting information on the performance deposit money banks in Nigeria. Time series data was collected from financial statements from 2010 to 2017. Return on asset, return on equity, return on investment and net profit margin was modeled as the function of debt equity ratio, retention rate, dividend payment rate, total investment and asset turnover. Multiple regressions with econometric view were used as data analysis methods. Regression coefficient, Durbin Watson, coefficient of determination, F-statistics and T-Statistics was used to determine the effect accounting information and performance of deposit money banks. Model one found that debts equity ratio has negative and significant effect on return on equity. Retention rate, divided payout rate, total investment and asset turnover have positive and significant effect on return on equity. Model two found that debts equity ratio and total investment   have positive and significant effect on return on investment while retention rate, dividend payout rate and assets turnover have negative effect on return on investment of commercial banks. Model three found that all the independent variables have negative effect o return on assets of deposit money banks while model four found that that debts equity ratio has negative and significant effect on net profit margin while other variables have positive effect on net profit margin. The study concludes significant effect of accounting information and performance of deposit money banks. We recommend that strategies should be device to manage accounting information