Abstract: The study investigated the relationship between human capital and performance of universities in South-South, Nigeria. A sample of twenty-nine (29) universities in South-South was drawn from the population of universities in Nigeria. The study utilized the cross-sectional research design. Data for the study were obtained using primary sources. The obtained data were analyzed using variance based (PLS – SEM) approach. This study found that human capital contributes significantly towards measures of university performance (student achievement and discipline referrals). It was recommended amongst others that the university and government authority should encourage and invest on research programmes for academic staff. It will help improve the already existing knowledge.