Ceiba Petandra is widely used in complementary medicine. Its stem bark extracts obtained via soxhlet extraction using n-hexane, acetone and ethanol gare alkaloids, Steroids, Saponins, Cardiac glycosides, triterpenes and tannins when screened phytochemically. These extracts were further investigated for their antibacterial activity against staphylococcus aureus klebsiella, pneumoniae and pseudomonas aeruginosa with ampicillina, as standard. Highest anti- bacterial activity with acetone extract at a concentration of 300mg/ml and least activity with ethanol extract at a concentration of 100mg/ml. n- Hexane extract showed no inhibition on the tested micro-organisms.