This study examined the indicators of tourist patronage and the constraints to tourism development across selected tourist destinations in Lagos, Nigeria. This study adopted a mixed-method approach, combining quantitative and qualitative techniques for comprehensive analysis. A multi-stage sampling technique was employed to select respondents from six categories of tourist destinations: private beaches, public beaches, entertainment and parks, gardens and conservation centers, shopping malls and plazas, and museums and cultural/religious centers. A sample size of 180 tourists was derived based on tourist arrival statistics obtained from the Lagos State Ministry of Tourism and destination managers, representing 10% of visitors to selected high-traffic sites. A total of 165 valid questionnaires were retrieved and analyzed. Data collection was carried out through structured questionnaires, while data analysis involved descriptive statistics (frequency and percentages) and inferential tools (chi-square, correlation, and regression analysis). The findings revealed that beauty of scenery (mean = 4.62), attractiveness (4.46), cleanliness (4.27), hospitality (4.19), friendliness (4.16), and quality of food (4.15) are key indicators influencing tourist patronage. These factors highlight the importance of environmental esthetics, service quality, and cultural experiences in shaping tourists’ decisions and satisfaction levels. However, the study also identified major constraints to tourism development, including accommodation (mean = 3.79), lack of funding (3.77), poor facilities management and maintenance (3.73), inadequate accessibility (3.72), lack of awareness and publicity (3.72), insecurity (3.70), inadequate facilities (3.65), and poor infrastructure (3.53). Further analysis using regression revealed that the cost of accommodation and inadequate facilities have a statistically significant negative effect on tourist patronage at the 0.05 level, with coefficients of -0.239 and -0.263 respectively. The model explained 16.9% (R² = 0.169) of the variation in tourist patronage, indicating that other factors also contribute to tourists’ behavior while constraints significantly influence tourism demand. The study concludes that although Lagos State possesses considerable tourism potential driven by attractive destinations and cultural richness, structural and economic constraints hinder optimal development and patronage. It recommends improved investment in infrastructure, accommodation costs reduction, enhanced marketing strategies, and strengthened policy implementation to boost tourism growth and sustainability.