Higher education in the fourth industrial revolution (HE 4.0) is a complex, dialectical and exciting opportunity which can potentially transform society for the better. The fourth industrial revolution is powered by artificial intelligence and it will transform the workplace from tasks-based characteristics to the human centered characteristics. Because of the convergence of man and machine, it will reduce the subject distance between humanities and social science as well as science and technology. This will necessarily require much more interdisciplinary teaching, research and innovation. This paper explores the impact of HE 4.0 on the mission of a university which is teaching, research (including innovation) and service in the perspective of Bangladesh