This study determined the influence of Student-teacher Relationship and Instructional Facilities on employability skills acquisition among Business Education students in tertiary institutions in Cross River State, Nigeria. Survey research design was employed in carrying out the study. Data were collected using a researcher-made questionnaire which was validated by two Vocational Educators and an expert in Measurement and Evaluation. A reliability estimate of .88, .79 and .87 was achieved for the research variables using Cronbach Alpha Statistical Analysis, after a trial test was conducted using 20 final year Business Education students (University of Uyo) who did not form part of the main study sample. The questionnaire was administered to 400 final year Business Education students using stratified and accidental sampling techniques. Data analysis was done, while two hypotheses were formulated and tested for significance using Simple Linear Regression Statistical Technique. Analyzed data were presented in form of tables and the results revealed significant influence of: student-teacher relationship and provision of instructional facilities on employability skills acquisition among Business Education Students. Based on the findings of the study, it was recommended among others that instructional facilities such as computers, and other reprographic materials needed for the students to acquire the right employability skills should be provided in the schools