Lassa fever is a deadly disease transmitted through ingestion of food that is contaminated with infected rodent’s saliva, urine or excreta, infected person and inhalation of the aerosol. In this paper, we investigated the sensitivity analysis of the transmission dynamics of Lassa fever model with personal protection and treatment controls earlier constructed. The existence of the steady state of the model was determined, after which the effective reproduction number of the model was computed using the next generation matrix approach. Sensitivity analysis was then carried out to determine which parameters that should be targeted by intervention strategies. The result revealed that increase in personal protection, treatment rate and rate of recovery with temporary immunity leads to a reduction in the spread of Lassa fever