This study predicted the provision of information and inventory services on entrepreneurial skills acquisition among senior secondary school students in Calabar Education Zone, Cross River State, Nigeria. The research design that was used for this study is the correlational research design. The stratified and simple random sampling techniques were employed to select a sample of 592 SS II students from a population of 5,918 for the study. A questionnaire titled “Inventory Services and Entrepreneurship Skills Acquisition Questionnaire (ISESAQ)" developed by the researcher was used in collecting data on six sub-variables involved in the study. The reliability estimates of the sub-scales ranged from .71 to .83 which showed that the instrument was reliable for data collection. The Simple Regression statistical analysis was used to test the hypotheses at .05 level of significance and 591 degrees of freedom. The results of the statistical analysis from the hypotheses showed that inventory service significantly predicts entrepreneurship skills acquisition among secondary school students in Calabar education zone, Cross River State, Nigeria. It was recommended among others that school counsellors should create awareness on inventory services in order to enhance employable skills acquisition among secondary school students. Counsellors should increase the level of publicity of inventory programmes and its services in the secondary schools. The programmes will help to address the needs of the students so as to enhance their economic empowerment skills.