Antiplasmodial And Anti-Inflammatory Activities Of Ethanolic Extract Of Hyptis Spicigera (Labiate)
Ishaya Kato Auta
Department of Biological Science, Kaduna State University, Kaduna, Nigeria
Keywords: Antiplasmodial, anti-inflammatory, ethanolic extract, leaf, Oedema, Hyptis spicigera
Abstract
The extracts of Hyptis spicigera is known for its analgesic activity. In northern Nigeria, it is used for the treatment of fever as well as evil spirit related diseases and for repelling mosquitoes. The activity of ethanolic leaves extract of this plant on antiplasmodia and anti-inflamation has not been investigated. This study is aimed at assessing the anti-plasmodial and anti-inflammation in mice and rats. The study was carried out using rodent Plasnnodia (Plasmodium berghei) in mice and egg albumin induced inflammation in rats. The LD50 of the extract was established to be 1059± 0.51 mg/kg i.p in mice. The result showed that the extract exhibited sufficient antiplasmodial activity in the models used, giving a suppressive activity of 54.02 - 64-12% and exhibited a significant curative effect of 2.83 ± 1.33 to 2.67 ± 2.28. The extracts gave a significant anti-inflammatory value against egg albumin induced inflammation in Laboratory rats. The phytochemical analysis of the plant extract indicated the presence of Flavonoids, Saponin, Glycoside, Tannins and Phenols. The observed pharmacological activity might be the scientific basis for the folkoric use of the plant in treating fever attack