Evaluation Of Selected Cardio-Inflammatory And Oxidative Stress Biomarkers Among Addicted Consumers Of Ogogoro (Local Gin) In Amassoma, Bayelsa State, Nigeria
Egoro, E.T
Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Niger Delta University, P.M.B. 071, Wilberforce Island, Bayelsa State, Nigeria
Onyasi, A.A
Department of Chemical Pathology, Federal University, Otuoke, Bayelsa State, Nigeria
Eboh, A.
Department of Biochemistry, Faculty of Basic Medical Sciences, Niger Delta University, P.M.B. 071, Wilberforce Island, Bayelsa State, Nigeria
Keywords: Ogogoro (local gin) addicts, cardio-inflammatory, oxidative stress, evaluation, Amassoma, Bayelsa State, Nigeria
Abstract
Ogogoro is a local gin that is consumed indiscriminately in Nigeria and some West African countries. The aim of this study was to investigate selected cardio-inflammatory and oxidative stress biomarkers among ogogoro addicts in Amassoma, Bayelsa State, Nigeria. Three milliliters of blood specimens were withdrawn from each of the 34 participants that constituted this study, with 17 being experimental group and the other 17 being control group, these specimens were dispensed into lithium heparin anti-coagulated bottles respectively. Each of these specimen was spun at 1,500 revolution / minute with the obtained plasma used for the measurement of cardiac biomarkers: troponin-1 (immune-turbidimetry) method and creatinekinase-MB (immune-inhibition) method, inflammatory biomarkers: C-reactive protein (latex turbidimetry) method and interleukin 6 (ELISA) method, oxidative stress biomarkers: malondialdehyde (thiobarbituric acid) method, glutathione peroxidase (immune-inhibitory) method and 8-hydroxy-2-deoxyguanosine (ELISA) method. The data obtained from these measurements were analyzed using SPSS version 23.0 (SPSS Inc., Chicago, IL, USA; version 23.0) while student “t” test was used in comparing the values of the biomarkers between the control and experimental groups with p < 0.05 considered significant. The results revealed significant mean levels elevations in C-reactive protein (p = 0.02), interleukin-6 (p = 0.02), and malondialdehyde (p = 0.01) in the experimental group as compared with that of the control group while there was significant decrease in glutathione peroxidase (p = 0.01) in the experimental group compared with that of the control group. However, the other measured biomarkers: troponin-1 (p = 0.58), creatinekinase-MB (0.62) and 8-hydroxy-2-deoxyguanosine (p = 0.67) revealed no significant alterations in the experimental group when compared with the control group. In conclusion, ogogoro addicts are at the risk of inflammatory and oxidative stress disorders, hence it is recommended that addicts of this local gin should check these biomarkers regularly in any reputable health facility
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